SLC2A2
Gene Information
- Official Symbol: SLC2A2
- Official Name: solute carrier family 2 member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6514
- UniProt: P11168
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
- UniProt Summary: Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16013
- Expression level (log2 read counts): -7.68
SLC2A2 Expression in NALM6 Cells: -7.68
