Entrez Summary: This gene encodes a GDP-fucose transporter that is found in the Golgi apparatus. Mutations in this gene result in congenital disorder of glycosylation type IIc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
UniProt Summary: Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.
Pfam DomainsGO Terms
Pfam Domains
TPT
EamA
UAA
GO Terms
GDP-fucose transmembrane transporter activity
purine nucleotide-sugar transmembrane transport
GDP-fucose import into Golgi lumen
GDP-fucose transmembrane transport
protein O-linked fucosylation
lipid glycosylation
nucleotide-sugar transmembrane transport
fucosylation
antiporter activity
negative regulation of Notch signaling pathway
transmembrane transporter activity
carbohydrate derivative transport
carbohydrate transport
regulation of Notch signaling pathway
protein O-linked glycosylation
lipid modification
nucleobase-containing compound transport
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
cellular lipid metabolic process
Golgi apparatus
carbohydrate derivative metabolic process
lipid metabolic process
negative regulation of signal transduction
transmembrane transport
negative regulation of cell communication
negative regulation of signaling
organonitrogen compound biosynthetic process
negative regulation of response to stimulus
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
nitrogen compound transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)