SLC6A2
Gene Information
- Official Symbol: SLC6A2
- Official Name: solute carrier family 6 member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6530
- UniProt: P23975
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010].
- UniProt Summary: Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. {ECO:0000269|PubMed:2008212}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6525
- Expression level (log2 read counts): -2.31
SLC6A2 Expression in NALM6 Cells: -2.31
