SLC6A5
Gene Information
- Official Symbol: SLC6A5
- Official Name: solute carrier family 6 member 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 9152
- UniProt: Q9Y345
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
- UniProt Summary: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses. {ECO:0000269|PubMed:10381548, ECO:0000269|PubMed:10606742, ECO:0000269|PubMed:9845349}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7785
- Expression level (log2 read counts): -3.08
SLC6A5 Expression in NALM6 Cells: -3.08
