Entrez Summary: This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
FHA
GO Terms
regulation of voltage-gated sodium channel activity
regulation of membrane depolarization during cardiac muscle cell action potential
regulation of membrane depolarization during action potential
smooth endoplasmic reticulum
regulation of cardiac muscle cell action potential
regulation of membrane depolarization
regulation of action potential
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
regulation of sodium ion transport
sarcolemma
microtubule organizing center
regulation of cation channel activity
protein localization to plasma membrane
protein localization to cell periphery
muscle contraction
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
muscle system process
regulation of cation transmembrane transport
regulation of metal ion transport
regulation of membrane potential
regulation of ion transmembrane transport
protein localization to membrane
regulation of transmembrane transport
regulation of ion transport
ion homeostasis
chemical homeostasis
integral component of plasma membrane
cellular protein localization
cellular macromolecule localization
homeostatic process
regulation of transport
system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)