UniProt Summary: Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
CH
CAMSAP CH
GO Terms
contractile fiber
tropomyosin binding
I band
protein phosphatase 1 binding
M band
positive regulation of vasoconstriction
filamentous actin
negative regulation of blood vessel diameter
regulation of vasoconstriction
positive regulation of blood circulation
regulation of tube diameter
regulation of blood vessel diameter
regulation of tube size
microtubule organizing center
vascular process in circulatory system
calmodulin binding
regulation of blood circulation
blood circulation
circulatory system process
actin cytoskeleton organization
regulation of anatomical structure size
actin filament-based process
regulation of system process
cytoskeleton organization
positive regulation of multicellular organismal process
system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: N/A