UniProt Summary: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
Pfam DomainsGO Terms
Pfam Domains
PDZ
GO Terms
dystrophin-associated glycoprotein complex
transport vesicle membrane
intracellular
structural molecule activity
calmodulin binding
synapse
actin binding
microtubule
focal adhesion
protein-containing complex
RNA binding
membrane
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739