SOX17

Gene Information

Official Symbol: SOX17
Official Name: SRY-box transcription factor 17
Aliases and Previous Symbols: N/A
Entrez ID: 64321
UniProt: Q9H6I2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Pfam Domains

DUF3547

HMG box

GO Terms

regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification

cardiogenic plate morphogenesis

endodermal cell fate determination

endodermal digestive tract morphogenesis

inner cell mass cellular morphogenesis

regulation of cardiac cell fate specification

regulation of transcription involved in primary germ layer cell fate commitment

gall bladder development

cardiac cell fate determination

negative regulation of mesoderm formation

negative regulation of mesodermal cell fate specification

stem cell fate specification

endocardium formation

negative regulation of mesodermal cell differentiation

common bile duct development

negative regulation of Wnt signaling pathway involved in heart development

negative regulation of cell fate specification

regulation of Wnt signaling pathway involved in heart development

endocardium morphogenesis

endodermal cell fate specification

regulation of mesoderm formation

inner cell mass cell differentiation

regulation of mesodermal cell fate specification

regulation of mesodermal cell differentiation

negative regulation of gastrulation

cardiac endothelial cell differentiation

negative regulation of mesoderm development

endocardial cell differentiation

embryonic foregut morphogenesis

regulation of stem cell division

stem cell fate commitment

cardiac cell fate commitment

foregut morphogenesis

regulation of cell fate specification

rostrocaudal neural tube patterning

endodermal cell fate commitment

negative regulation of cell fate commitment

heart formation

endocardium development

cell migration involved in gastrulation

regulation of mesoderm development

regulation of transcription involved in cell fate commitment

mRNA transcription by RNA polymerase II

signal transduction involved in regulation of gene expression

nuclear transcription factor complex

positive regulation of skeletal muscle tissue development

mRNA transcription

negative regulation of embryonic development

regulation of cell fate commitment

cell fate commitment involved in formation of primary germ layer

neural tube patterning

animal organ formation

regulation of gastrulation

blastocyst formation

cell fate determination

endodermal cell differentiation

protein destabilization

endoderm formation

digestive tract morphogenesis

regulation of skeletal muscle tissue development

regulation of cardiocyte differentiation

heart looping

regulation of stem cell proliferation

embryonic heart tube morphogenesis

determination of heart left/right asymmetry

vasculogenesis

positive regulation of striated muscle tissue development

positive regulation of muscle organ development

positive regulation of muscle tissue development

outflow tract morphogenesis

endoderm development

embryonic heart tube development

endothelial cell differentiation

beta-catenin binding

cell fate specification

canonical Wnt signaling pathway

endothelium development

response to leukemia inhibitory factor

cellular response to leukemia inhibitory factor

blastocyst development

formation of primary germ layer

cardiocyte differentiation

determination of left/right symmetry

determination of bilateral symmetry

specification of symmetry

regulation of embryonic development

hepaticobiliary system development

digestive tract development

regulation of striated muscle tissue development

regulation of muscle tissue development

regulation of muscle organ development

digestive system development

stem cell differentiation

gastrulation

neural tube development

regulation of cell division

ameboidal-type cell migration

negative regulation of canonical Wnt signaling pathway

protein stabilization

negative regulation of cell growth

transcription factor complex

negative regulation of Wnt signaling pathway

positive regulation of protein catabolic process

anterior/posterior pattern specification

transcription regulatory region DNA binding

negative regulation of growth

cell fate commitment

heart morphogenesis

regulation of animal organ morphogenesis

regulation of canonical Wnt signaling pathway

renal system development

transcription coactivator activity

regulation of protein stability

embryonic organ morphogenesis

epithelial tube morphogenesis

angiogenesis

urogenital system development

transcription factor binding

regionalization

Wnt signaling pathway

cell-cell signaling by wnt

regulation of Wnt signaling pathway

in utero embryonic development

regulation of protein catabolic process

blood vessel morphogenesis

regulation of cell growth

sequence-specific DNA binding

cell surface receptor signaling pathway involved in cell-cell signaling

positive regulation of catabolic process

morphogenesis of an epithelium

embryonic organ development

pattern specification process

DNA-binding transcription activator activity, RNA polymerase II-specific

transcription by RNA polymerase II

blood vessel development

protein heterodimerization activity

vasculature development

cardiovascular system development

heart development

spermatogenesis

cell morphogenesis involved in differentiation

male gamete generation

tissue morphogenesis

embryonic morphogenesis

chordate embryonic development

transcription, DNA-templated

nucleic acid-templated transcription

embryo development ending in birth or egg hatching

RNA biosynthetic process

tube morphogenesis

regulation of growth

epithelial cell differentiation

gamete generation

mRNA metabolic process

negative regulation of cell differentiation

cell morphogenesis

cellular component morphogenesis

multicellular organismal reproductive process

sexual reproduction

multicellular organism reproduction

tube development

negative regulation of transcription by RNA polymerase II

circulatory system development

anatomical structure formation involved in morphogenesis

negative regulation of developmental process

animal organ morphogenesis

cell migration

positive regulation of cell differentiation

embryo development

regulation of catabolic process

multi-organism reproductive process

cellular response to cytokine stimulus

regulation of anatomical structure morphogenesis

localization of cell

cell motility

nucleobase-containing compound biosynthetic process

response to cytokine

epithelium development

cell-cell signaling

heterocycle biosynthetic process

aromatic compound biosynthetic process

negative regulation of transcription, DNA-templated

negative regulation of multicellular organismal process

positive regulation of transcription by RNA polymerase II

negative regulation of nucleic acid-templated transcription

negative regulation of RNA biosynthetic process

negative regulation of signal transduction

organic cyclic compound biosynthetic process

locomotion

negative regulation of RNA metabolic process

negative regulation of cell communication

negative regulation of signaling

positive regulation of developmental process

negative regulation of cellular macromolecule biosynthetic process

reproductive process

reproduction

negative regulation of nucleobase-containing compound metabolic process

negative regulation of macromolecule biosynthetic process

negative regulation of cellular biosynthetic process

positive regulation of transcription, DNA-templated

negative regulation of biosynthetic process

movement of cell or subcellular component

DNA-binding transcription factor activity, RNA polymerase II-specific

regulation of cell population proliferation

negative regulation of response to stimulus

cellular nitrogen compound biosynthetic process

positive regulation of nucleic acid-templated transcription

positive regulation of RNA biosynthetic process

cell development

RNA metabolic process

positive regulation of protein metabolic process

cellular macromolecule biosynthetic process

negative regulation of gene expression

positive regulation of RNA metabolic process

positive regulation of multicellular organismal process

tissue development

macromolecule biosynthetic process

regulation of cell differentiation

positive regulation of nucleobase-containing compound metabolic process

positive regulation of macromolecule biosynthetic process

positive regulation of cellular biosynthetic process

positive regulation of gene expression

gene expression

positive regulation of biosynthetic process

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
Bisphenol S 100μM R08 exp458	-1.84
Colchicine 0.009μM R05 exp215	-1.78
Pifithrin-alpha 20μM R07 exp390	1.78

Most Correlated Genes in Chemogenomics

Gene	Correlation
PRIM1	0.402

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16654
Expression level (log2 read counts): -3.08

Expression Distribution