UniProt Summary: May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
Kazal 2
Kazal 1
GO Terms
negative regulation of acrosome reaction
negative regulation of fertilization
regulation of acrosome reaction
regulation of fertilization
negative regulation of reproductive process
serine-type endopeptidase inhibitor activity
regulation of reproductive process
negative regulation of multi-organism process
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of proteolysis
regulation of multi-organism process
negative regulation of catalytic activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
extracellular region
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)