SPOPL
Gene Information
- Official Symbol: SPOPL
- Official Name: speckle type BTB/POZ protein like
- Aliases and Previous Symbols: N/A
- Entrez ID: 339745
- UniProt: Q6IQ16
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. {ECO:0000269|PubMed:22632832}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17148
- Expression level (log2 read counts): 4.81
SPOPL Expression in NALM6 Cells: 4.81
