SPRY1
Gene Information
- Official Symbol: SPRY1
- Official Name: sprouty RTK signaling antagonist 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 10252
- UniProt: O43609
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
Pfam Domains GO Terms
Pfam Domains
| Sprouty |
GO Terms
| epithelial to mesenchymal transition involved in cardiac fibroblast development |
| epicardium-derived cardiac fibroblast cell development |
| cardiac fibroblast cell differentiation |
| epicardium-derived cardiac fibroblast cell differentiation |
| cardiac fibroblast cell development |
| negative regulation of neurotrophin TRK receptor signaling pathway |
| bud elongation involved in lung branching |
| regulation of neurotrophin TRK receptor signaling pathway |
| organ induction |
| negative regulation of fibroblast growth factor receptor signaling pathway |
| branch elongation of an epithelium |
| epithelial tube branching involved in lung morphogenesis |
| axis elongation |
| developmental induction |
| cardiac epithelial to mesenchymal transition |
| establishment of mitotic spindle orientation |
| regulation of fibroblast growth factor receptor signaling pathway |
| establishment of mitotic spindle localization |
| establishment of spindle orientation |
| regulation of animal organ formation |
| establishment of spindle localization |
| lung morphogenesis |
| negative regulation of epidermal growth factor receptor signaling pathway |
| negative regulation of GTPase activity |
| spindle localization |
| negative regulation of ERBB signaling pathway |
| negative regulation of Ras protein signal transduction |
| negative regulation of small GTPase mediated signal transduction |
| cardiac cell development |
| negative regulation of ERK1 and ERK2 cascade |
| epithelial to mesenchymal transition |
| negative regulation of MAP kinase activity |
| positive regulation of animal organ morphogenesis |
| metanephros development |
| regulation of epidermal growth factor receptor signaling pathway |
| ureteric bud development |
| mesonephric tubule development |
| mesonephric epithelium development |
| regulation of ERBB signaling pathway |
| mesonephros development |
| microtubule cytoskeleton organization involved in mitosis |
| developmental growth involved in morphogenesis |
| cardiocyte differentiation |
| establishment of cell polarity |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| negative regulation of protein serine/threonine kinase activity |
| negative regulation of cellular response to growth factor stimulus |
| mesenchymal cell differentiation |
| morphogenesis of a branching epithelium |
| negative regulation of MAPK cascade |
| morphogenesis of a branching structure |
| lung development |
| respiratory tube development |
| respiratory system development |
| establishment or maintenance of cell polarity |
| mesenchyme development |
| negative regulation of protein kinase activity |
| regulation of Ras protein signal transduction |
| negative regulation of kinase activity |
| heart morphogenesis |
| regulation of animal organ morphogenesis |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| negative regulation of transferase activity |
| renal system development |
| regulation of ERK1 and ERK2 cascade |
| epithelial tube morphogenesis |
| urogenital system development |
| regulation of MAP kinase activity |
| regulation of small GTPase mediated signal transduction |
| establishment of organelle localization |
| developmental growth |
| growth |
| negative regulation of protein phosphorylation |
| morphogenesis of an epithelium |
| negative regulation of phosphorylation |
| negative regulation of hydrolase activity |
| microtubule cytoskeleton organization |
| regulation of GTPase activity |
| negative regulation of intracellular signal transduction |
| regulation of protein serine/threonine kinase activity |
| heart development |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| organelle localization |
| negative regulation of protein modification process |
| mitotic cell cycle process |
| tube morphogenesis |
| microtubule-based process |
| negative regulation of cell population proliferation |
| mitotic cell cycle |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| tube development |
| circulatory system development |
| regulation of kinase activity |
| animal organ morphogenesis |
| regulation of transferase activity |
| Golgi apparatus |
| cell cycle process |
| negative regulation of cellular protein metabolic process |
| regulation of anatomical structure morphogenesis |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| epithelium development |
| negative regulation of molecular function |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cell development |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| DABN 2μM R00 exp16 | 1.87 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8101
- Expression level (log2 read counts): 3.03
Expression Distribution
SPRY1 Expression in NALM6 Cells: 3.03
