STAP1
Gene Information
- Official Symbol: STAP1
- Official Name: signal transducing adaptor family member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 26228
- UniProt: Q9ULZ2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
- UniProt Summary: In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. {ECO:0000269|PubMed:10518561}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| negative regulation of microglial cell migration |
| negative regulation of macrophage colony-stimulating factor signaling pathway |
| negative regulation of response to macrophage colony-stimulating factor |
| negative regulation of cellular response to macrophage colony-stimulating factor stimulus |
| regulation of microglial cell mediated cytotoxicity |
| macrophage colony-stimulating factor receptor binding |
| regulation of macrophage colony-stimulating factor signaling pathway |
| positive regulation of microglial cell mediated cytotoxicity |
| negative regulation of glial cell migration |
| negative regulation of ruffle assembly |
| regulation of cellular response to macrophage colony-stimulating factor stimulus |
| regulation of response to macrophage colony-stimulating factor |
| positive regulation of non-membrane spanning protein tyrosine kinase activity |
| negative regulation of macrophage chemotaxis |
| regulation of microglial cell migration |
| regulation of non-membrane spanning protein tyrosine kinase activity |
| positive regulation of microglial cell activation |
| positive regulation of B cell receptor signaling pathway |
| negative regulation of macrophage migration |
| positive regulation of phagocytosis, engulfment |
| transmembrane receptor protein tyrosine kinase adaptor activity |
| positive regulation of membrane invagination |
| positive regulation of neuroinflammatory response |
| regulation of phagocytosis, engulfment |
| regulation of glial cell migration |
| regulation of membrane invagination |
| negative regulation of leukocyte chemotaxis |
| regulation of microglial cell activation |
| positive regulation of actin cytoskeleton reorganization |
| positive regulation of antigen receptor-mediated signaling pathway |
| positive regulation of macrophage activation |
| negative regulation of plasma membrane bounded cell projection assembly |
| regulation of B cell receptor signaling pathway |
| regulation of macrophage chemotaxis |
| regulation of ruffle assembly |
| regulation of neuroinflammatory response |
| regulation of macrophage migration |
| regulation of actin cytoskeleton reorganization |
| phosphotyrosine residue binding |
| negative regulation of gliogenesis |
| negative regulation of leukocyte migration |
| regulation of macrophage activation |
| SH3/SH2 adaptor activity |
| positive regulation of leukocyte mediated cytotoxicity |
| positive regulation of protein tyrosine kinase activity |
| negative regulation of chemotaxis |
| negative regulation of cytokine-mediated signaling pathway |
| regulation of antigen receptor-mediated signaling pathway |
| negative regulation of response to cytokine stimulus |
| positive regulation of cell killing |
| positive regulation of phagocytosis |
| regulation of leukocyte mediated cytotoxicity |
| regulation of protein tyrosine kinase activity |
| regulation of phagocytosis |
| positive regulation of endocytosis |
| regulation of cell killing |
| phospholipid binding |
| regulation of leukocyte chemotaxis |
| regulation of gliogenesis |
| positive regulation of inflammatory response |
| regulation of cytokine-mediated signaling pathway |
| regulation of response to cytokine stimulus |
| negative regulation of cell projection organization |
| cellular response to lipopolysaccharide |
| positive regulation of peptidyl-tyrosine phosphorylation |
| cellular response to molecule of bacterial origin |
| regulation of leukocyte migration |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| regulation of endocytosis |
| regulation of chemotaxis |
| cellular response to biotic stimulus |
| positive regulation of cytoskeleton organization |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of cell migration |
| negative regulation of cell motility |
| negative regulation of neurogenesis |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| response to lipopolysaccharide |
| negative regulation of locomotion |
| response to molecule of bacterial origin |
| negative regulation of cell development |
| regulation of inflammatory response |
| regulation of actin cytoskeleton organization |
| negative regulation of response to external stimulus |
| regulation of actin filament-based process |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| protein kinase binding |
| positive regulation of defense response |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cellular response to lipid |
| positive regulation of protein kinase activity |
| regulation of cytoskeleton organization |
| regulation of vesicle-mediated transport |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| positive regulation of kinase activity |
| protein-containing complex |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| positive regulation of organelle organization |
| regulation of cell activation |
| positive regulation of transferase activity |
| intracellular membrane-bounded organelle |
| response to bacterium |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of defense response |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| regulation of cell migration |
| response to lipid |
| positive regulation of immune response |
| regulation of kinase activity |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15243
- Expression level (log2 read counts): 6.9
Expression Distribution
STAP1 Expression in NALM6 Cells: 6.9
