STAR
Gene Information
- Official Symbol: STAR
- Official Name: steroidogenic acute regulatory protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 6770
- UniProt: P49675
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008].
- UniProt Summary: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Pfam Domains GO Terms
Pfam Domains
| START |
GO Terms
| phthalate metabolic process |
| circadian sleep/wake cycle, REM sleep |
| insecticide metabolic process |
| positive regulation of bile acid metabolic process |
| biphenyl metabolic process |
| positive regulation of bile acid biosynthetic process |
| circadian sleep/wake cycle, sleep |
| cellular response to luteinizing hormone stimulus |
| dibenzo-p-dioxin metabolic process |
| circadian sleep/wake cycle process |
| response to luteinizing hormone |
| testosterone biosynthetic process |
| mitochondrial crista |
| circadian sleep/wake cycle |
| regulation of bile acid biosynthetic process |
| response to fungicide |
| cellular response to follicle-stimulating hormone stimulus |
| cellular response to interferon-alpha |
| regulation of bile acid metabolic process |
| response to herbicide |
| estrogen biosynthetic process |
| cellular response to epinephrine stimulus |
| sleep |
| C21-steroid hormone biosynthetic process |
| response to follicle-stimulating hormone |
| glucocorticoid metabolic process |
| intracellular cholesterol transport |
| response to epinephrine |
| response to insecticide |
| intracellular sterol transport |
| positive regulation of steroid biosynthetic process |
| cellular response to gonadotropin stimulus |
| response to corticosterone |
| response to interferon-alpha |
| cellular response to growth hormone stimulus |
| response to leptin |
| toxin metabolic process |
| circadian behavior |
| rhythmic behavior |
| response to lead ion |
| benzene-containing compound metabolic process |
| bile acid biosynthetic process |
| positive regulation of steroid metabolic process |
| ketone biosynthetic process |
| response to gonadotropin |
| C21-steroid hormone metabolic process |
| cellular response to dexamethasone stimulus |
| response to mineralocorticoid |
| estrogen metabolic process |
| response to growth hormone |
| cellular response to alkaloid |
| intracellular lipid transport |
| bile acid metabolic process |
| cellular response to cadmium ion |
| response to dexamethasone |
| steroid hormone biosynthetic process |
| cholesterol binding |
| response to nicotine |
| regulation of neuronal synaptic plasticity |
| cholesterol transport |
| cellular response to cAMP |
| secondary metabolic process |
| cellular response to glucocorticoid stimulus |
| cellular response to corticosteroid stimulus |
| hormone biosynthetic process |
| response to cadmium ion |
| response to activity |
| sterol transport |
| cellular response to glucose stimulus |
| cellular ketone metabolic process |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| response to estrogen |
| mitochondrial intermembrane space |
| positive regulation of lipid biosynthetic process |
| cellular response to carbohydrate stimulus |
| phenol-containing compound metabolic process |
| regulation of steroid biosynthetic process |
| cellular glucose homeostasis |
| cellular response to ketone |
| response to antineoplastic agent |
| dicarboxylic acid metabolic process |
| response to cAMP |
| cellular response to monoamine stimulus |
| cellular response to catecholamine stimulus |
| antibiotic metabolic process |
| response to monoamine |
| response to catecholamine |
| cellular response to fibroblast growth factor stimulus |
| diterpenoid metabolic process |
| response to alkaloid |
| regulation of steroid metabolic process |
| response to fibroblast growth factor |
| cellular response to antibiotic |
| cholesterol metabolic process |
| response to hydrogen peroxide |
| terpenoid metabolic process |
| cellular hormone metabolic process |
| steroid biosynthetic process |
| response to ethanol |
| secondary alcohol metabolic process |
| xenobiotic metabolic process |
| sterol metabolic process |
| male gonad development |
| development of primary male sexual characteristics |
| response to organophosphorus |
| response to glucose |
| isoprenoid metabolic process |
| positive regulation of small molecule metabolic process |
| organic hydroxy compound transport |
| circadian rhythm |
| positive regulation of lipid metabolic process |
| response to hexose |
| negative regulation of neuron apoptotic process |
| response to glucocorticoid |
| response to ionizing radiation |
| response to monosaccharide |
| response to purine-containing compound |
| cellular response to transforming growth factor beta stimulus |
| male sex differentiation |
| response to corticosteroid |
| cellular response to interferon-gamma |
| response to transforming growth factor beta |
| cellular response to insulin stimulus |
| response to carbohydrate |
| regulation of cellular ketone metabolic process |
| response to interferon-gamma |
| cellular response to lipopolysaccharide |
| glucose homeostasis |
| monocarboxylic acid biosynthetic process |
| organic hydroxy compound biosynthetic process |
| carbohydrate homeostasis |
| cellular response to xenobiotic stimulus |
| regulation of lipid biosynthetic process |
| cellular response to steroid hormone stimulus |
| regulation of synaptic plasticity |
| cellular response to molecule of bacterial origin |
| cellular response to metal ion |
| response to ketone |
| response to reactive oxygen species |
| hormone metabolic process |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| gonad development |
| response to nutrient |
| cellular response to biotic stimulus |
| development of primary sexual characteristics |
| cellular response to inorganic substance |
| response to insulin |
| response to alcohol |
| steroid metabolic process |
| sex differentiation |
| cellular response to peptide hormone stimulus |
| rhythmic process |
| lipid transport |
| response to xenobiotic stimulus |
| carboxylic acid biosynthetic process |
| response to antibiotic |
| organic acid biosynthetic process |
| regulation of neuron death |
| response to lipopolysaccharide |
| alcohol metabolic process |
| neuron projection |
| lipid localization |
| cellular response to peptide |
| response to molecule of bacterial origin |
| response to steroid hormone |
| response to metal ion |
| neuronal cell body |
| response to oxidative stress |
| response to peptide hormone |
| regulation of lipid metabolic process |
| cellular response to drug |
| reproductive structure development |
| regulation of small molecule metabolic process |
| reproductive system development |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| organic hydroxy compound metabolic process |
| positive regulation of neurogenesis |
| response to peptide |
| response to nutrient levels |
| drug metabolic process |
| cellular response to growth factor stimulus |
| response to toxic substance |
| cellular response to lipid |
| monocarboxylic acid metabolic process |
| response to growth factor |
| response to extracellular stimulus |
| response to inorganic substance |
| regulation of hormone levels |
| positive regulation of nervous system development |
| positive regulation of cell development |
| cellular response to organic cyclic compound |
| behavior |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| response to bacterium |
| brain development |
| cellular chemical homeostasis |
| innate immune response |
| head development |
| regulation of neurogenesis |
| response to lipid |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| response to hormone |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| defense response to other organism |
| cellular lipid metabolic process |
| positive regulation of cell differentiation |
| central nervous system development |
| negative regulation of cell death |
| response to organonitrogen compound |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| response to drug |
| organic acid metabolic process |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| response to cytokine |
| chemical homeostasis |
| response to abiotic stimulus |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| mitochondrion |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| intracellular transport |
| generation of neurons |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| neurogenesis |
| homeostatic process |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| immune response |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UMK57 0.6μM R03 exp107 | -1.78 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.433 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8770
- Expression level (log2 read counts): 0.81
Expression Distribution
STAR Expression in NALM6 Cells: 0.81
