STC2
Gene Information
- Official Symbol: STC2
- Official Name: stanniocalcin 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 8614
- UniProt: O76061
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
Pfam Domains GO Terms
Pfam Domains
| Stanniocalcin |
GO Terms
| negative regulation of multicellular organism growth |
| regulation of store-operated calcium entry |
| decidualization |
| regulation of hormone biosynthetic process |
| response to vitamin D |
| maternal placenta development |
| embryo implantation |
| regulation of hormone metabolic process |
| maternal process involved in female pregnancy |
| regulation of multicellular organism growth |
| response to vitamin |
| hormone activity |
| negative regulation of developmental growth |
| endoplasmic reticulum unfolded protein response |
| cellular response to unfolded protein |
| heme binding |
| cellular response to topologically incorrect protein |
| placenta development |
| response to unfolded protein |
| female pregnancy |
| response to topologically incorrect protein |
| cellular response to hypoxia |
| cellular response to decreased oxygen levels |
| multi-multicellular organism process |
| cellular response to oxygen levels |
| response to nutrient |
| negative regulation of growth |
| regulation of calcium ion transport |
| response to endoplasmic reticulum stress |
| endoplasmic reticulum lumen |
| regulation of developmental growth |
| response to hypoxia |
| enzyme binding |
| response to decreased oxygen levels |
| post-translational protein modification |
| response to oxygen levels |
| regulation of metal ion transport |
| response to oxidative stress |
| response to peptide hormone |
| reproductive structure development |
| reproductive system development |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| divalent inorganic cation homeostasis |
| response to nutrient levels |
| response to extracellular stimulus |
| regulation of hormone levels |
| cellular metal ion homeostasis |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| developmental process involved in reproduction |
| regulation of growth |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| response to lipid |
| protein homodimerization activity |
| cellular homeostasis |
| response to hormone |
| response to organic cyclic compound |
| negative regulation of developmental process |
| Golgi apparatus |
| multi-organism reproductive process |
| response to organonitrogen compound |
| endoplasmic reticulum |
| response to nitrogen compound |
| chemical homeostasis |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| extracellular space |
| homeostatic process |
| cellular response to stress |
| negative regulation of gene expression |
| tissue development |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.413 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8478
- Expression level (log2 read counts): 6.92
Expression Distribution
STC2 Expression in NALM6 Cells: 6.92
