SV2B
Gene Information
- Official Symbol: SV2B
- Official Name: synaptic vesicle glycoprotein 2B
- Aliases and Previous Symbols: N/A
- Entrez ID: 9899
- UniProt: Q7L1I2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016].
- UniProt Summary: Probably plays a role in the control of regulated secretion in neural and endocrine cells. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6262
- Expression level (log2 read counts): 2.31
SV2B Expression in NALM6 Cells: 2.31
