Pfam Domains GO Terms
| SYF2 |
| post-mRNA release spliceosomal complex |
| Prp19 complex |
| mitotic G2 DNA damage checkpoint |
| mitotic G2/M transition checkpoint |
| G2 DNA damage checkpoint |
| U2-type catalytic step 2 spliceosome |
| catalytic step 2 spliceosome |
| negative regulation of G2/M transition of mitotic cell cycle |
| mitotic DNA damage checkpoint |
| negative regulation of cell cycle G2/M phase transition |
| mitotic DNA integrity checkpoint |
| DNA damage checkpoint |
| DNA integrity checkpoint |
| mitotic cell cycle checkpoint |
| gastrulation |
| cell cycle checkpoint |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| negative regulation of cell cycle phase transition |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| in utero embryonic development |
| RNA splicing |
| nuclear speck |
| regulation of mitotic cell cycle phase transition |
| embryonic organ development |
| regulation of cell cycle phase transition |
| mRNA processing |
| embryonic morphogenesis |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| mitotic cell cycle |
| mRNA metabolic process |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| RNA processing |
| positive regulation of cell population proliferation |
| embryo development |
| cell cycle process |
| regulation of cell cycle |
| cell cycle |
| RNA binding |
| regulation of cell population proliferation |
| RNA metabolic process |
| cellular response to stress |
| gene expression |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| NFN1 0.1μM R01 exp49 | 1.71 |
| Etoposide 0.3μM R05 exp199 | 1.92 |
| Gene | Correlation |
|---|---|
| PRIM1 | 0.45 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 21/28 |
| blood | 19/28 |
| bone | 13/26 |
| breast | 27/33 |
| central nervous system | 40/56 |
| cervix | 4/4 |
| colorectal | 15/17 |
| esophagus | 11/13 |
| fibroblast | 1/1 |
| gastric | 11/16 |
| kidney | 16/21 |
| liver | 14/20 |
| lung | 61/75 |
| lymphocyte | 12/16 |
| ovary | 24/26 |
| pancreas | 16/24 |
| peripheral nervous system | 13/16 |
| plasma cell | 10/15 |
| prostate | 1/1 |
| skin | 16/24 |
| soft tissue | 9/9 |
| thyroid | 1/2 |
| upper aerodigestive | 19/22 |
| urinary tract | 23/29 |
| uterus | 5/5 |
Expression Distribution