TAF8

Entrez Summary: N/A
UniProt Summary: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). {ECO:0000250, ECO:0000269|PubMed:14580349}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM R07 exp318	1.93

Gene	Correlation
POLR2J3	0.427

Global Fraction of Cell Lines Where Essential: 384/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	20/28
blood	7/28
bone	15/25
breast	13/33
central nervous system	28/56
cervix	2/4
colorectal	9/17
esophagus	4/13
fibroblast	0/1
gastric	10/15
kidney	15/21
liver	8/20
lung	37/75
lymphocyte	10/14
ovary	13/26
pancreas	10/24
peripheral nervous system	10/16
plasma cell	9/15
prostate	0/1
skin	19/24
soft tissue	4/7
thyroid	2/2
upper aerodigestive	9/22
urinary tract	15/29
uterus	3/5

Expression Distribution