TAL1
Gene Information
- Official Symbol: TAL1
- Official Name: TAL bHLH transcription factor 1, erythroid differentiation factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 6886
- UniProt: P17542
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:1396592}.
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| Lsd1/2 complex |
| hemangioblast cell differentiation |
| basophil differentiation |
| regulation of mast cell differentiation |
| positive regulation of chromatin assembly or disassembly |
| astrocyte fate commitment |
| primitive hemopoiesis |
| regulation of chromatin assembly or disassembly |
| negative regulation of erythrocyte differentiation |
| hematopoietic stem cell differentiation |
| spinal cord association neuron differentiation |
| glial cell fate commitment |
| erythrocyte maturation |
| definitive hemopoiesis |
| megakaryocyte development |
| granulocyte differentiation |
| platelet formation |
| platelet morphogenesis |
| embryonic hemopoiesis |
| megakaryocyte differentiation |
| dorsal spinal cord development |
| bone cell development |
| mesodermal cell differentiation |
| regulation of stem cell population maintenance |
| positive regulation of erythrocyte differentiation |
| erythrocyte development |
| positive regulation of signaling receptor activity |
| histone deacetylase complex |
| regulation of erythrocyte differentiation |
| E-box binding |
| astrocyte differentiation |
| cell differentiation in spinal cord |
| positive regulation of protein tyrosine kinase activity |
| myeloid cell development |
| RNA polymerase II transcription factor binding |
| mesoderm formation |
| mesoderm morphogenesis |
| regulation of hematopoietic stem cell differentiation |
| negative regulation of myeloid cell differentiation |
| erythrocyte differentiation |
| regulation of hematopoietic progenitor cell differentiation |
| hematopoietic progenitor cell differentiation |
| positive regulation of cell division |
| regulation of protein tyrosine kinase activity |
| erythrocyte homeostasis |
| positive regulation of myeloid cell differentiation |
| RNA polymerase II distal enhancer sequence-specific DNA binding |
| positive regulation of chromatin organization |
| myeloid cell homeostasis |
| spinal cord development |
| formation of primary germ layer |
| histone deacetylase binding |
| myeloid leukocyte differentiation |
| regulation of myeloid leukocyte differentiation |
| regulation of stem cell differentiation |
| mesoderm development |
| anatomical structure maturation |
| negative regulation of hemopoiesis |
| positive regulation of mitotic cell cycle |
| stem cell differentiation |
| cell maturation |
| gastrulation |
| regulation of cell division |
| glial cell differentiation |
| regulation of signaling receptor activity |
| positive regulation of chromosome organization |
| central nervous system neuron differentiation |
| positive regulation of hemopoiesis |
| regulation of chromatin organization |
| positive regulation of peptidyl-tyrosine phosphorylation |
| locomotory behavior |
| homeostasis of number of cells |
| bone development |
| transcription factor complex |
| gliogenesis |
| transcription regulatory region DNA binding |
| myeloid cell differentiation |
| regulation of myeloid cell differentiation |
| nuclear chromatin |
| developmental maturation |
| cell fate commitment |
| positive regulation of protein complex assembly |
| regulation of peptidyl-tyrosine phosphorylation |
| regulation of leukocyte differentiation |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| angiogenesis |
| leukocyte differentiation |
| enzyme binding |
| regulation of chromosome organization |
| positive regulation of cell cycle |
| chromatin binding |
| blood vessel morphogenesis |
| embryonic organ development |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| regulation of protein complex assembly |
| transcription by RNA polymerase II |
| blood vessel development |
| protein heterodimerization activity |
| skeletal system development |
| vasculature development |
| cardiovascular system development |
| positive regulation of cellular component biogenesis |
| positive regulation of protein kinase activity |
| hemopoiesis |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| behavior |
| positive regulation of kinase activity |
| hematopoietic or lymphoid organ development |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| immune system development |
| RNA biosynthetic process |
| tube morphogenesis |
| positive regulation of transferase activity |
| DNA-binding transcription factor activity |
| negative regulation of cell differentiation |
| cell morphogenesis |
| regulation of protein kinase activity |
| cellular component morphogenesis |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| embryo development |
| central nervous system development |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| nucleobase-containing compound biosynthetic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7680
- Expression level (log2 read counts): 0.74
Expression Distribution
TAL1 Expression in NALM6 Cells: 0.74
