UniProt Summary: Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. {ECO:0000250|UniProtKB:Q8R3D1}.
Pfam DomainsGO Terms
Pfam Domains
TBC
GO Terms
regulation of cilium assembly
activation of GTPase activity
Rab GTPase binding
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
GTPase activator activity
positive regulation of GTPase activity
regulation of GTPase activity
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
positive regulation of hydrolase activity
regulation of cellular component biogenesis
intracellular protein transport
regulation of hydrolase activity
regulation of organelle organization
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport
membrane
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739