Entrez Summary: This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
SPO22
GO Terms
meiotic gene conversion
male meiosis chromosome segregation
gene conversion
chiasma assembly
central element
resolution of meiotic recombination intermediates
synaptonemal complex assembly
meiotic chromosome separation
synaptonemal complex organization
synaptonemal complex
chromosome separation
synapsis
male meiotic nuclear division
reciprocal meiotic recombination
homologous recombination
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
meiotic chromosome segregation
meiosis I
meiosis I cell cycle process
male gonad development
development of primary male sexual characteristics
meiotic nuclear division
male sex differentiation
meiotic cell cycle process
fertilization
gonad development
development of primary sexual characteristics
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
sex differentiation
chromosome segregation
nuclear division
organelle fission
cellular process involved in reproduction in multicellular organism
reproductive structure development
reproductive system development
male gamete generation
developmental process involved in reproduction
gamete generation
DNA metabolic process
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
multi-organism reproductive process
cell cycle process
chromosome organization
cell cycle
reproductive process
reproduction
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694