UniProt Summary: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. {ECO:0000250|UniProtKB:Q9CQP8}.
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
CatSper complex
sperm principal piece
sperm capacitation
male meiotic nuclear division
flagellated sperm motility
sperm motility
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
spermatid development
meiotic nuclear division
spermatid differentiation
cell maturation
meiotic cell cycle process
meiotic cell cycle
developmental maturation
germ cell development
nuclear division
organelle fission
cellular process involved in reproduction in multicellular organism
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
cell cycle process
cell motility
localization of cell
locomotion
cell cycle
reproductive process
reproduction
movement of cell or subcellular component
cell development
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: N/A