TFAP4
Gene Information
- Official Symbol: TFAP4
- Official Name: transcription factor AP-4
- Aliases and Previous Symbols: N/A
- Entrez ID: 7023
- UniProt: Q01664
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'- CAGCTG-3'.
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| negative regulation by host of viral transcription |
| DNA damage response, signal transduction resulting in transcription |
| positive regulation by host of viral transcription |
| regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| negative regulation of cell cycle arrest |
| negative regulation of viral transcription |
| negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| cellular response to dexamethasone stimulus |
| negative regulation of cyclin-dependent protein kinase activity |
| response to dexamethasone |
| positive regulation of viral transcription |
| E-box binding |
| negative regulation of DNA binding |
| cellular response to glucocorticoid stimulus |
| transcriptional repressor complex |
| cellular response to corticosteroid stimulus |
| regulation of viral transcription |
| modification by host of symbiont morphology or physiology |
| interaction with symbiont |
| DNA damage response, signal transduction by p53 class mediator |
| cellular response to ketone |
| response to antineoplastic agent |
| negative regulation of viral process |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| signal transduction in response to DNA damage |
| regulation of cell cycle arrest |
| positive regulation of viral process |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| histone deacetylase binding |
| signal transduction by p53 class mediator |
| regulation of DNA binding |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of protein serine/threonine kinase activity |
| response to glucocorticoid |
| positive regulation of cysteine-type endopeptidase activity |
| modification of morphology or physiology of other organism |
| response to corticosteroid |
| negative regulation of binding |
| positive regulation of endopeptidase activity |
| positive regulation of apoptotic signaling pathway |
| cellular response to xenobiotic stimulus |
| cellular response to steroid hormone stimulus |
| positive regulation of peptidase activity |
| response to ketone |
| regulation of viral process |
| negative regulation of multi-organism process |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| transcription regulatory region DNA binding |
| regulation of symbiosis, encompassing mutualism through parasitism |
| negative regulation of protein kinase activity |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of kinase activity |
| negative regulation of transferase activity |
| transcription coactivator activity |
| response to xenobiotic stimulus |
| negative regulation of cell cycle process |
| response to steroid hormone |
| positive regulation of proteolysis |
| positive regulation of cell cycle |
| regulation of binding |
| regulation of apoptotic signaling pathway |
| cellular response to drug |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| regulation of endopeptidase activity |
| sequence-specific DNA binding |
| regulation of peptidase activity |
| negative regulation of phosphorylation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of cell cycle phase transition |
| protein heterodimerization activity |
| positive regulation of multi-organism process |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| cellular response to organic cyclic compound |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| cellular response to hormone stimulus |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| negative regulation of cell population proliferation |
| DNA-binding transcription factor activity |
| positive regulation of cell death |
| regulation of proteolysis |
| regulation of cell cycle process |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| symbiotic process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| response to lipid |
| regulation of kinase activity |
| protein homodimerization activity |
| response to hormone |
| response to organic cyclic compound |
| regulation of transferase activity |
| response to drug |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| regulation of hydrolase activity |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 11/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 2/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1434
- Expression level (log2 read counts): 5.74
Expression Distribution
TFAP4 Expression in NALM6 Cells: 5.74
