TIAM1
Gene Information
- Official Symbol: TIAM1
- Official Name: TIAM Rac1 associated GEF 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7074
- UniProt: Q13009
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. {ECO:0000269|PubMed:20361982}.
Pfam Domains GO Terms
Pfam Domains
| RBD |
| RhoGEF |
| PDZ |
| PH |
GO Terms
| positive regulation of Schwann cell chemotaxis |
| regulation of Schwann cell chemotaxis |
| NMDA selective glutamate receptor signaling pathway |
| positive regulation of Schwann cell migration |
| regulation of Schwann cell migration |
| extrinsic component of postsynaptic density membrane |
| regulation of modification of postsynaptic actin cytoskeleton |
| main axon |
| regulation of modification of postsynaptic structure |
| positive regulation of glial cell migration |
| regulation of dopaminergic neuron differentiation |
| regulation of modification of synaptic structure |
| regulation of glial cell migration |
| Rac guanyl-nucleotide exchange factor activity |
| positive regulation of dendritic spine morphogenesis |
| cell-cell contact zone |
| Rac protein signal transduction |
| regulation of non-canonical Wnt signaling pathway |
| ionotropic glutamate receptor signaling pathway |
| axonal growth cone |
| cardiac muscle hypertrophy |
| striated muscle hypertrophy |
| muscle hypertrophy |
| positive regulation of dendrite morphogenesis |
| regulation of dendritic spine morphogenesis |
| positive regulation of dendritic spine development |
| glutamate receptor signaling pathway |
| positive regulation of epithelial to mesenchymal transition |
| response to cocaine |
| receptor tyrosine kinase binding |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| neuron projection extension |
| extrinsic component of cytoplasmic side of plasma membrane |
| positive regulation of gliogenesis |
| Rho guanyl-nucleotide exchange factor activity |
| positive regulation of JUN kinase activity |
| positive regulation of dendrite development |
| regulation of dendritic spine development |
| response to anesthetic |
| regulation of epithelial to mesenchymal transition |
| positive regulation of axonogenesis |
| ephrin receptor signaling pathway |
| regulation of JUN kinase activity |
| developmental cell growth |
| cell growth |
| regulation of dendrite morphogenesis |
| kinase binding |
| positive regulation of protein binding |
| ruffle membrane |
| regulation of postsynapse organization |
| Wnt signaling pathway, planar cell polarity pathway |
| activation of GTPase activity |
| guanyl-nucleotide exchange factor activity |
| regulation of establishment of planar polarity |
| response to alkaloid |
| developmental growth involved in morphogenesis |
| regulation of gliogenesis |
| cell-matrix adhesion |
| non-canonical Wnt signaling pathway |
| positive regulation of chemotaxis |
| positive regulation of JNK cascade |
| regulation of Rho protein signal transduction |
| dendritic spine |
| regulation of dendrite development |
| positive regulation of cell morphogenesis involved in differentiation |
| lipid binding |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| cell-cell junction |
| regulation of insulin secretion |
| positive regulation of binding |
| regulation of morphogenesis of an epithelium |
| response to ammonium ion |
| regulation of axonogenesis |
| cell-substrate adhesion |
| regulation of JNK cascade |
| regulation of peptide hormone secretion |
| regulation of chemotaxis |
| regulation of synapse organization |
| regulation of protein binding |
| regulation of synapse structure or activity |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| microtubule binding |
| regulation of Ras protein signal transduction |
| Ras protein signal transduction |
| regulation of animal organ morphogenesis |
| positive regulation of MAP kinase activity |
| regulation of hormone secretion |
| positive regulation of neuron projection development |
| regulation of ERK1 and ERK2 cascade |
| muscle system process |
| response to xenobiotic stimulus |
| regulation of cell morphogenesis involved in differentiation |
| microtubule |
| small GTPase mediated signal transduction |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of small GTPase mediated signal transduction |
| glutamatergic synapse |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| positive regulation of neuron differentiation |
| neuronal cell body |
| regulation of binding |
| positive regulation of cell projection organization |
| developmental growth |
| growth |
| positive regulation of GTPase activity |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of protein secretion |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| protein localization to membrane |
| regulation of GTPase activity |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| positive regulation of cell migration |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cell motility |
| regulation of hormone levels |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| positive regulation of locomotion |
| positive regulation of kinase activity |
| positive regulation of response to external stimulus |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| neuron projection development |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| regulation of protein transport |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cell migration |
| regulation of kinase activity |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| cell migration |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| response to organonitrogen compound |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| regulation of protein localization |
| programmed cell death |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| cell death |
| regulation of response to external stimulus |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| locomotion |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| OICR-9429 10μM R03 exp142 | 1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7720
- Expression level (log2 read counts): 5.05
Expression Distribution
TIAM1 Expression in NALM6 Cells: 5.05
