TIAM2
Gene Information
- Official Symbol: TIAM2
- Official Name: TIAM Rac1 associated GEF 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 26230
- UniProt: Q8IVF5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10955
- Expression level (log2 read counts): 3.83
TIAM2 Expression in NALM6 Cells: 3.83
