TLE6
Gene Information
- Official Symbol: TLE6
- Official Name: TLE family member 6, subcortical maternal complex member
- Aliases and Previous Symbols: N/A
- Entrez ID: 79816
- UniProt: Q9H808
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
- UniProt Summary: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. {ECO:0000269|PubMed:26537248}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3735
- Expression level (log2 read counts): 2.55
TLE6 Expression in NALM6 Cells: 2.55
