TMC8
Gene Information
- Official Symbol: TMC8
- Official Name: transmembrane channel like 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 147138
- UniProt: Q8IU68
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008].
- UniProt Summary: Probable ion channel. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3236
- Expression level (log2 read counts): 3.0
TMC8 Expression in NALM6 Cells: 3.0
