UniProt Summary: Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. {ECO:0000250|UniProtKB:Q9CZ16}.
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
negative regulation of osteoclast differentiation
negative regulation of myeloid leukocyte differentiation
regulation of osteoclast differentiation
negative regulation of myeloid cell differentiation
negative regulation of leukocyte differentiation
regulation of myeloid leukocyte differentiation
negative regulation of hemopoiesis
regulation of myeloid cell differentiation
regulation of leukocyte differentiation
regulation of cytosolic calcium ion concentration
cellular calcium ion homeostasis
negative regulation of immune system process
calcium ion homeostasis
regulation of hemopoiesis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
negative regulation of cell differentiation
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
endoplasmic reticulum membrane
negative regulation of developmental process
chemical homeostasis
negative regulation of multicellular organismal process
homeostatic process
regulation of immune system process
regulation of cell differentiation
membrane
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739