TMEM38B
Gene Information
- Official Symbol: TMEM38B
- Official Name: transmembrane protein 38B
- Aliases and Previous Symbols: N/A
- Entrez ID: 55151
- UniProt: Q9NVV0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012].
- UniProt Summary: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. {ECO:0000250|UniProtKB:Q9DAV9}.
Pfam Domains GO Terms
Pfam Domains
| TRIC |
GO Terms
| secretion by lung epithelial cell involved in lung growth |
| extracellular matrix constituent secretion |
| lung growth |
| release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| release of sequestered calcium ion into cytosol by endoplasmic reticulum |
| cellular response to caffeine |
| cellular response to purine-containing compound |
| sarcoplasmic reticulum calcium ion transport |
| response to diuretic |
| response to caffeine |
| regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| lung epithelial cell differentiation |
| lung cell differentiation |
| regulation of cardiac muscle contraction by calcium ion signaling |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| potassium channel activity |
| lung epithelium development |
| sarcoplasmic reticulum membrane |
| cellular response to alkaloid |
| lung alveolus development |
| bone mineralization |
| endoplasmic reticulum organization |
| release of sequestered calcium ion into cytosol |
| negative regulation of sequestering of calcium ion |
| calcium ion transmembrane import into cytosol |
| calcium ion transport into cytosol |
| regulation of cardiac muscle contraction |
| regulation of release of sequestered calcium ion into cytosol |
| cytosolic calcium ion transport |
| regulation of striated muscle contraction |
| biomineral tissue development |
| biomineralization |
| organ growth |
| regulation of calcium ion transport into cytosol |
| response to alkaloid |
| regulation of sequestering of calcium ion |
| calcium-mediated signaling |
| regulation of calcium ion transmembrane transport |
| response to purine-containing compound |
| potassium ion transmembrane transport |
| regulation of muscle contraction |
| potassium ion transport |
| lung development |
| respiratory tube development |
| cellular response to xenobiotic stimulus |
| respiratory system development |
| calcium ion transmembrane transport |
| bone development |
| regulation of muscle system process |
| nuclear membrane |
| regulation of heart contraction |
| phospholipid biosynthetic process |
| regulation of calcium ion transport |
| calcium ion transport |
| ossification |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| divalent metal ion transport |
| response to xenobiotic stimulus |
| divalent inorganic cation transport |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| extracellular matrix organization |
| phospholipid metabolic process |
| extracellular structure organization |
| regulation of metal ion transport |
| developmental growth |
| growth |
| monovalent inorganic cation transport |
| cellular response to drug |
| endomembrane system organization |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| skeletal system development |
| organophosphate biosynthetic process |
| cellular response to organic cyclic compound |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| lipid biosynthetic process |
| regulation of system process |
| cellular response to organonitrogen compound |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| cellular response to nitrogen compound |
| epithelial cell differentiation |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| tube development |
| organophosphate metabolic process |
| cellular homeostasis |
| regulation of cellular localization |
| response to organic cyclic compound |
| ion transmembrane transport |
| cellular lipid metabolic process |
| response to organonitrogen compound |
| secretion by cell |
| response to drug |
| export from cell |
| response to nitrogen compound |
| chemical homeostasis |
| epithelium development |
| secretion |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| transmembrane transport |
| ion transport |
| response to endogenous stimulus |
| homeostatic process |
| intracellular signal transduction |
| tissue development |
| establishment of localization in cell |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BRD2 inhibitor II 20μM R07 exp341 | 1.86 |
| Metformin 100 to 150μM on day4 R04 exp170 | 1.9 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13422
- Expression level (log2 read counts): 3.98
Expression Distribution
TMEM38B Expression in NALM6 Cells: 3.98
