TMPRSS11D
Gene Information
- Official Symbol: TMPRSS11D
- Official Name: transmembrane serine protease 11D
- Aliases and Previous Symbols: N/A
- Entrez ID: 9407
- UniProt: O60235
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. {ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:24227843}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11084
- Expression level (log2 read counts): -0.06
TMPRSS11D Expression in NALM6 Cells: -0.06
