TNFRSF12A
Gene Information
- Official Symbol: TNFRSF12A
- Official Name: TNF receptor superfamily member 12A
- Aliases and Previous Symbols: N/A
- Entrez ID: 51330
- UniProt: Q9NP84
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}.
Pfam Domains GO Terms
Pfam Domains
| stn TNFRSF12A |
GO Terms
| substrate-dependent cell migration, cell attachment to substrate |
| substrate-dependent cell migration |
| positive regulation of axon extension |
| positive regulation of extrinsic apoptotic signaling pathway |
| positive regulation of axonogenesis |
| ruffle |
| regulation of axon extension |
| extrinsic apoptotic signaling pathway |
| regulation of extent of cell growth |
| tumor necrosis factor-mediated signaling pathway |
| regulation of wound healing |
| regulation of extrinsic apoptotic signaling pathway |
| positive regulation of cell morphogenesis involved in differentiation |
| positive regulation of cell growth |
| regulation of response to wounding |
| positive regulation of developmental growth |
| positive regulation of apoptotic signaling pathway |
| regulation of cell size |
| regulation of axonogenesis |
| cell-substrate adhesion |
| cellular response to tumor necrosis factor |
| positive regulation of growth |
| response to tumor necrosis factor |
| positive regulation of neuron projection development |
| apoptotic signaling pathway |
| regulation of angiogenesis |
| regulation of cell morphogenesis involved in differentiation |
| angiogenesis |
| regulation of vasculature development |
| regulation of developmental growth |
| positive regulation of neuron differentiation |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of apoptotic signaling pathway |
| blood vessel morphogenesis |
| regulation of cell growth |
| positive regulation of neurogenesis |
| blood vessel development |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| vasculature development |
| regulation of anatomical structure size |
| cardiovascular system development |
| positive regulation of nervous system development |
| positive regulation of cell development |
| cell surface |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| tube morphogenesis |
| regulation of neuron differentiation |
| regulation of growth |
| cytokine-mediated signaling pathway |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| regulation of cell projection organization |
| regulation of neurogenesis |
| tube development |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| apoptotic process |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| cell migration |
| positive regulation of cell differentiation |
| cellular response to cytokine stimulus |
| programmed cell death |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| cell death |
| response to cytokine |
| positive regulation of cellular component organization |
| locomotion |
| positive regulation of developmental process |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| neurogenesis |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Lead acetate 990μM R08 exp496 | 1.9 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13826
- Expression level (log2 read counts): -0.16
Expression Distribution
TNFRSF12A Expression in NALM6 Cells: -0.16
