TNFSF4
Gene Information
- Official Symbol: TNFSF4
- Official Name: TNF superfamily member 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 7292
- UniProt: P23510
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
- UniProt Summary: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Pfam Domains GO Terms
Pfam Domains
| TNF |
GO Terms
| response to nitrogen dioxide |
| regulation of interleukin-4-dependent isotype switching to IgE isotypes |
| positive regulation of CD4-positive, alpha-beta T cell costimulation |
| chemokine (C-C motif) ligand 11 production |
| T-helper 2 cell activation |
| positive regulation of interleukin-4-dependent isotype switching to IgE isotypes |
| positive regulation of T cell costimulation |
| memory T cell activation |
| defense response to nematode |
| regulation of CD4-positive, alpha-beta T cell costimulation |
| negative regulation of T-helper 1 cell differentiation |
| regulation of T cell costimulation |
| positive regulation of isotype switching to IgE isotypes |
| tumor necrosis factor receptor superfamily binding |
| negative regulation of regulatory T cell differentiation |
| regulation of isotype switching to IgE isotypes |
| positive regulation of memory T cell differentiation |
| negative regulation of T-helper 1 type immune response |
| positive regulation of T-helper 2 cell differentiation |
| chemokine production |
| regulation of memory T cell differentiation |
| regulation of T-helper 1 cell differentiation |
| regulation of T-helper 2 cell differentiation |
| positive regulation of immunoglobulin secretion |
| negative regulation of interleukin-17 production |
| positive regulation of interleukin-13 production |
| negative regulation of T-helper cell differentiation |
| positive regulation of type 2 immune response |
| cellular response to prostaglandin E stimulus |
| positive regulation of T cell cytokine production |
| regulation of immunoglobulin secretion |
| positive regulation of alpha-beta T cell proliferation |
| negative regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of T-helper cell differentiation |
| cellular response to prostaglandin stimulus |
| regulation of interleukin-13 production |
| response to prostaglandin E |
| positive regulation of interleukin-4 production |
| negative regulation of alpha-beta T cell differentiation |
| positive regulation of isotype switching |
| regulation of T-helper 1 type immune response |
| regulation of interleukin-4 production |
| regulation of interleukin-17 production |
| negative regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of regulatory T cell differentiation |
| regulation of type 2 immune response |
| regulation of alpha-beta T cell proliferation |
| response to prostaglandin |
| tumor necrosis factor receptor binding |
| regulation of T cell cytokine production |
| negative regulation of interferon-gamma production |
| regulation of isotype switching |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| regulation of T-helper cell differentiation |
| positive regulation of interleukin-12 production |
| positive regulation of interleukin-10 production |
| positive regulation of immunoglobulin mediated immune response |
| positive regulation of B cell mediated immunity |
| negative regulation of alpha-beta T cell activation |
| positive regulation of DNA recombination |
| CD4-positive, alpha-beta T cell activation |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of immunoglobulin production |
| negative regulation of T cell differentiation |
| negative regulation of adaptive immune response |
| positive regulation of alpha-beta T cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of T cell mediated immunity |
| regulation of immunoglobulin mediated immune response |
| regulation of B cell mediated immunity |
| regulation of interleukin-10 production |
| negative regulation of lymphocyte differentiation |
| positive regulation of cytokine production involved in immune response |
| regulation of interleukin-12 production |
| cellular response to fatty acid |
| positive regulation of alpha-beta T cell activation |
| regulation of CD4-positive, alpha-beta T cell activation |
| alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| regulation of immunoglobulin production |
| positive regulation of interferon-gamma production |
| regulation of T cell mediated immunity |
| acute inflammatory response |
| positive regulation of T cell differentiation |
| regulation of cytokine production involved in immune response |
| cellular response to alcohol |
| response to fatty acid |
| cellular response to ketone |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| positive regulation of interleukin-6 production |
| positive regulation of T cell proliferation |
| positive regulation of production of molecular mediator of immune response |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of leukocyte differentiation |
| regulation of DNA recombination |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| negative regulation of T cell activation |
| tumor necrosis factor-mediated signaling pathway |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte mediated immunity |
| negative regulation of hemopoiesis |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| positive regulation of inflammatory response |
| regulation of interleukin-6 production |
| regulation of production of molecular mediator of immune response |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of lymphocyte activation |
| positive regulation of leukocyte differentiation |
| negative regulation of immune response |
| cytokine production |
| regulation of lymphocyte mediated immunity |
| regulation of T cell proliferation |
| negative regulation of DNA-binding transcription factor activity |
| regulation of adaptive immune response |
| positive regulation of B cell activation |
| regulation of lymphocyte differentiation |
| cytokine activity |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| cellular response to lipopolysaccharide |
| positive regulation of hemopoiesis |
| cellular response to molecule of bacterial origin |
| positive regulation of DNA metabolic process |
| response to ketone |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| cellular response to acid chemical |
| regulation of mononuclear cell proliferation |
| cellular response to biotic stimulus |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| response to alcohol |
| T cell activation |
| cellular response to tumor necrosis factor |
| positive regulation of cell-cell adhesion |
| response to tumor necrosis factor |
| positive regulation of protein secretion |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| negative regulation of cytokine production |
| response to virus |
| positive regulation of peptide secretion |
| regulation of leukocyte cell-cell adhesion |
| response to lipopolysaccharide |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| signaling receptor binding |
| regulation of inflammatory response |
| response to acid chemical |
| regulation of DNA metabolic process |
| positive regulation of lymphocyte activation |
| lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| positive regulation of secretion |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of defense response |
| regulation of peptide secretion |
| inflammatory response |
| regulation of lymphocyte activation |
| cellular response to lipid |
| response to inorganic substance |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| cell surface |
| regulation of cell activation |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of secretion |
| response to lipid |
| positive regulation of immune response |
| response to hormone |
| positive regulation of cell population proliferation |
| leukocyte activation |
| negative regulation of developmental process |
| defense response to other organism |
| positive regulation of cell differentiation |
| positive regulation of transport |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| cell activation |
| response to nitrogen compound |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| integral component of plasma membrane |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| extracellular space |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Azithromycin 100μM R08 exp452 | -1.82 |
| THZ531 0.11 to 0.125μM on day4 R07 exp410 | -1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16359
- Expression level (log2 read counts): 1.21
Expression Distribution
TNFSF4 Expression in NALM6 Cells: 1.21
