TNKS1BP1

Gene Information

Official Symbol: TNKS1BP1
Official Name: tankyrase 1 binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 85456
UniProt: Q9C0C2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

Pfam Domains

No Pfam Domain information is available for this gene.

GO Terms

ankyrin repeat binding

CCR4-NOT complex

nuclear heterochromatin

telomere maintenance via telomerase

nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of protein autophosphorylation

positive regulation of peptidyl-threonine phosphorylation

telomere maintenance via telomere lengthening

RNA-dependent DNA biosynthetic process

regulation of peptidyl-threonine phosphorylation

regulation of protein autophosphorylation

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

intracellular signal transduction involved in G1 DNA damage checkpoint

signal transduction involved in mitotic DNA integrity checkpoint

signal transduction involved in mitotic cell cycle checkpoint

signal transduction involved in mitotic G1 DNA damage checkpoint

signal transduction involved in mitotic DNA damage checkpoint

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

mitotic G1 DNA damage checkpoint

mitotic G1/S transition checkpoint

G1 DNA damage checkpoint

cellular response to ionizing radiation

signal transduction involved in DNA damage checkpoint

signal transduction involved in DNA integrity checkpoint

signal transduction involved in cell cycle checkpoint

DNA damage response, signal transduction by p53 class mediator

positive regulation of cell cycle arrest

mitotic DNA damage checkpoint

telomere maintenance

telomere organization

negative regulation of G1/S transition of mitotic cell cycle

mitotic DNA integrity checkpoint

signal transduction in response to DNA damage

cell-cell adherens junction

positive regulation of peptidyl-serine phosphorylation

negative regulation of cell cycle G1/S phase transition

regulation of cell cycle arrest

DNA biosynthetic process

signal transduction by p53 class mediator

DNA damage checkpoint

regulation of peptidyl-serine phosphorylation

DNA integrity checkpoint

response to ionizing radiation

regulation of G1/S transition of mitotic cell cycle

mitotic cell cycle checkpoint

regulation of cell cycle G1/S phase transition

cellular response to radiation

double-strand break repair

cell cycle checkpoint

nuclear-transcribed mRNA catabolic process

negative regulation of mitotic cell cycle phase transition

mRNA catabolic process

negative regulation of cell cycle phase transition

RNA catabolic process

protein-containing complex binding

positive regulation of cell cycle process

negative regulation of mitotic cell cycle

cadherin binding

cellular response to environmental stimulus

cellular response to abiotic stimulus

negative regulation of cell cycle process

anatomical structure homeostasis

enzyme binding

cytoskeleton

nucleobase-containing compound catabolic process

positive regulation of cell cycle

regulation of mitotic cell cycle phase transition

heterocycle catabolic process

cellular nitrogen compound catabolic process

response to radiation

aromatic compound catabolic process

regulation of cell cycle phase transition

organic cyclic compound catabolic process

DNA repair

negative regulation of cell cycle

mitotic cell cycle process

regulation of mitotic cell cycle

mitotic cell cycle

mRNA metabolic process

DNA metabolic process

regulation of cell cycle process

cellular response to DNA damage stimulus

cellular macromolecule catabolic process

cell cycle process

positive regulation of protein phosphorylation

macromolecule catabolic process

positive regulation of phosphorylation

chromosome organization

nucleobase-containing compound biosynthetic process

positive regulation of phosphate metabolic process

positive regulation of phosphorus metabolic process

response to abiotic stimulus

heterocycle biosynthetic process

aromatic compound biosynthetic process

regulation of cell cycle

positive regulation of protein modification process

organic cyclic compound biosynthetic process

cell cycle

regulation of protein phosphorylation

regulation of phosphorylation

positive regulation of cellular protein metabolic process

cellular nitrogen compound biosynthetic process

homeostatic process

RNA metabolic process

intracellular signal transduction

cellular response to stress

positive regulation of protein metabolic process

cellular macromolecule biosynthetic process

negative regulation of gene expression

macromolecule biosynthetic process

organic substance catabolic process

regulation of phosphate metabolic process

regulation of phosphorus metabolic process

cellular catabolic process

regulation of protein modification process

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
Alpha-Amanitin 0.5μM R00 exp5	-1.87

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12369
Expression level (log2 read counts): 5.56

Expression Distribution