TPP1
Gene Information
- Official Symbol: TPP1
- Official Name: tripeptidyl peptidase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1200
- UniProt: O14773
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008].
- UniProt Summary: Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). {ECO:0000250|UniProtKB:Q9EQV6}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13153
- Expression level (log2 read counts): 7.4
TPP1 Expression in NALM6 Cells: 7.4
