Pfam Domains GO Terms
| Death |
| TRADD N |
| death domain binding |
| death-inducing signaling complex |
| death-inducing signaling complex assembly |
| positive regulation of hair follicle development |
| transmembrane receptor protein tyrosine kinase adaptor activity |
| positive regulation of hair cycle |
| regulation of hair follicle development |
| regulation of hair cycle |
| tumor necrosis factor receptor binding |
| extrinsic apoptotic signaling pathway via death domain receptors |
| negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| positive regulation of epidermis development |
| regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| regulation of tumor necrosis factor-mediated signaling pathway |
| I-kappaB kinase/NF-kappaB signaling |
| positive regulation of NIK/NF-kappaB signaling |
| regulation of epidermis development |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| kinase binding |
| extrinsic apoptotic signaling pathway |
| negative regulation of extrinsic apoptotic signaling pathway |
| protein heterooligomerization |
| regulation of NIK/NF-kappaB signaling |
| tumor necrosis factor-mediated signaling pathway |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of inflammatory response |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of extrinsic apoptotic signaling pathway |
| regulation of cytokine-mediated signaling pathway |
| positive regulation of endopeptidase activity |
| regulation of response to cytokine stimulus |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| positive regulation of peptidase activity |
| receptor complex |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of apoptotic signaling pathway |
| membrane raft |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| cellular response to tumor necrosis factor |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of DNA-binding transcription factor activity |
| response to tumor necrosis factor |
| protein-containing complex binding |
| apoptotic signaling pathway |
| regulation of inflammatory response |
| positive regulation of proteolysis |
| cytoskeleton |
| regulation of apoptotic signaling pathway |
| regulation of endopeptidase activity |
| regulation of DNA-binding transcription factor activity |
| regulation of peptidase activity |
| positive regulation of defense response |
| positive regulation of cell migration |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| protein complex oligomerization |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| positive regulation of response to external stimulus |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| cytokine-mediated signaling pathway |
| positive regulation of cell death |
| enzyme linked receptor protein signaling pathway |
| regulation of proteolysis |
| regulation of defense response |
| positive regulation of hydrolase activity |
| regulation of cell migration |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| apoptotic process |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| identical protein binding |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of response to stress |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| NMS-873 0.07μM R07 exp380 | -2.05 |
| Rapamycin 2μM R07 exp306 | -1.76 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution