TRIM27
Gene Information
- Official Symbol: TRIM27
- Official Name: tripartite motif containing 27
- Aliases and Previous Symbols: N/A
- Entrez ID: 5987
- UniProt: P14373
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T- cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double- stranded DNA. {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:23452853}.
Pfam Domains GO Terms
Pfam Domains
| zf-B box |
| zf-C3HC4 |
| SPRY |
GO Terms
| negative regulation of interleukin-2 secretion |
| regulation of interleukin-2 secretion |
| negative regulation of calcium ion import |
| interferon-gamma secretion |
| positive regulation of actin nucleation |
| negative regulation of viral release from host cell |
| interferon-gamma production |
| retromer complex |
| Arp2/3 complex-mediated actin nucleation |
| negative regulation of interleukin-2 production |
| negative regulation of viral transcription |
| regulation of actin nucleation |
| regulation of viral release from host cell |
| actin nucleation |
| regulation of calcium ion import |
| protein K63-linked ubiquitination |
| negative regulation of adaptive immune response |
| cytokine secretion |
| protein trimerization |
| regulation of interleukin-2 production |
| negative regulation of tumor necrosis factor production |
| negative regulation of calcium ion transport |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| regulation of viral transcription |
| negative regulation of cytokine secretion |
| negative regulation of viral life cycle |
| negative regulation of gene expression, epigenetic |
| positive regulation of actin filament polymerization |
| retrograde transport, endosome to Golgi |
| negative regulation of viral process |
| PML body |
| positive regulation of protein polymerization |
| negative regulation of protein secretion |
| fibrillar center |
| negative regulation of peptide secretion |
| regulation of viral life cycle |
| cytosolic transport |
| negative regulation of ion transport |
| negative regulation of immune response |
| regulation of tumor necrosis factor production |
| cytokine production |
| regulation of tumor necrosis factor superfamily cytokine production |
| protein secretion |
| establishment of protein localization to extracellular region |
| regulation of adaptive immune response |
| regulation of actin filament polymerization |
| protein localization to extracellular region |
| peptide secretion |
| negative regulation of protein transport |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| negative regulation of establishment of protein localization |
| nucleic acid binding |
| positive regulation of supramolecular fiber organization |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of viral process |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| positive regulation of cytoskeleton organization |
| ubiquitin protein ligase activity |
| regulation of protein polymerization |
| negative regulation of protein kinase activity |
| endosomal transport |
| negative regulation of secretion |
| regulation of gene expression, epigenetic |
| nuclear membrane |
| actin filament organization |
| negative regulation of kinase activity |
| ubiquitin-protein transferase activity |
| regulation of calcium ion transport |
| positive regulation of protein complex assembly |
| early endosome |
| regulation of actin filament organization |
| positive regulation of DNA-binding transcription factor activity |
| endosome |
| negative regulation of cytokine production |
| negative regulation of transferase activity |
| protein polyubiquitination |
| negative regulation of locomotion |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| regulation of cellular component size |
| regulation of metal ion transport |
| regulation of actin filament-based process |
| negative regulation of protein phosphorylation |
| regulation of DNA-binding transcription factor activity |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| regulation of protein secretion |
| negative regulation of transport |
| regulation of peptide secretion |
| actin cytoskeleton organization |
| regulation of anatomical structure size |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| spermatogenesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| male gamete generation |
| actin filament-based process |
| negative regulation of protein modification process |
| positive regulation of organelle organization |
| protein ubiquitination |
| gamete generation |
| regulation of cytokine production |
| regulation of ion transport |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| innate immune response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of secretion |
| multicellular organismal reproductive process |
| sexual reproduction |
| zinc ion binding |
| multicellular organism reproduction |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| defense response to other organism |
| regulation of cellular component biogenesis |
| regulation of transferase activity |
| regulation of locomotion |
| protein modification by small protein conjugation or removal |
| multi-organism reproductive process |
| secretion by cell |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| export from cell |
| identical protein binding |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| secretion |
| negative regulation of molecular function |
| regulation of immune response |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| protein transport |
| negative regulation of cellular biosynthetic process |
| intracellular transport |
| peptide transport |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| amide transport |
| regulation of phosphorylation |
| establishment of protein localization |
| negative regulation of response to stimulus |
| regulation of immune system process |
| negative regulation of gene expression |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM0129480 7μM R02 exp85 | -1.78 |
| Milciclib 2μM R08 exp502 | -1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16170
- Expression level (log2 read counts): 7.15
Expression Distribution
TRIM27 Expression in NALM6 Cells: 7.15
