Entrez Summary: The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Ion trans
GO Terms
calcium activated cation channel activity
cation channel activity
detection of temperature stimulus
sensory perception of temperature stimulus
calcium channel activity
detection of external stimulus
detection of abiotic stimulus
protein tetramerization
response to temperature stimulus
calcium ion transmembrane transport
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
protein complex oligomerization
inorganic cation transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
detection of stimulus
cation transport
ion transmembrane transport
sensory perception
response to abiotic stimulus
transmembrane transport
ion transport
nervous system process
protein-containing complex assembly
protein-containing complex subunit organization
system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739