TRPM6
Gene Information
- Official Symbol: TRPM6
- Official Name: transient receptor potential cation channel subfamily M member 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 140803
- UniProt: Q9BX84
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010].
- UniProt Summary: Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11580
- Expression level (log2 read counts): 2.89
TRPM6 Expression in NALM6 Cells: 2.89
