Pfam Domains GO Terms
| LRR 4 |
| ciliary body morphogenesis |
| anterior commissure morphogenesis |
| corpus callosum morphogenesis |
| lateral ventricle development |
| corpus callosum development |
| central nervous system projection neuron axonogenesis |
| ventricular system development |
| central nervous system neuron axonogenesis |
| central nervous system neuron development |
| camera-type eye morphogenesis |
| eye morphogenesis |
| central nervous system neuron differentiation |
| negative regulation of Wnt signaling pathway |
| sensory organ morphogenesis |
| telencephalon development |
| camera-type eye development |
| eye development |
| regulation of Wnt signaling pathway |
| visual system development |
| sensory system development |
| axonogenesis |
| forebrain development |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell part morphogenesis |
| sensory organ development |
| cell morphogenesis involved in differentiation |
| neuron projection development |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| cellular component morphogenesis |
| animal organ morphogenesis |
| central nervous system development |
| neuron differentiation |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| generation of neurons |
| extracellular space |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| LY2090314 0.003μM R08 exp500 no dilution day6 | -1.8 |
| Bortezomib 0.05μM R00 exp7 | 1.73 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution