UniProt Summary: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}.
Pfam DomainsGO Terms
Pfam Domains
Pkinase
Pkinase Tyr
GO Terms
acrosomal vesicle
centriole
spermatid development
spermatid differentiation
peptidyl-serine phosphorylation
protein autophosphorylation
peptidyl-serine modification
magnesium ion binding
germ cell development
protein-containing complex binding
cellular process involved in reproduction in multicellular organism
protein serine/threonine kinase activity
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
peptidyl-amino acid modification
protein phosphorylation
multi-organism reproductive process
phosphorylation
reproductive process
reproduction
ATP binding
cell development
intracellular signal transduction
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739