TWF2
Gene Information
- Official Symbol: TWF2
- Official Name: twinfilin actin binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 11344
- UniProt: Q6IBS0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Cofilin ADF |
GO Terms
| regulation of microvillus length |
| actin filament depolymerization |
| sequestering of actin monomers |
| regulation of cell projection size |
| regulation of microvillus organization |
| barbed-end actin filament capping |
| positive regulation of lamellipodium assembly |
| positive regulation of lamellipodium organization |
| actin monomer binding |
| myofibril |
| regulation of lamellipodium assembly |
| stereocilium |
| actin filament capping |
| negative regulation of actin filament depolymerization |
| protein depolymerization |
| regulation of lamellipodium organization |
| positive regulation of axon extension |
| actin polymerization or depolymerization |
| regulation of actin filament depolymerization |
| negative regulation of actin filament polymerization |
| protein kinase C binding |
| negative regulation of protein depolymerization |
| negative regulation of protein polymerization |
| cellular response to retinoic acid |
| negative regulation of protein complex disassembly |
| filopodium |
| maintenance of protein location in cell |
| phosphatidylinositol-4,5-bisphosphate binding |
| actin filament |
| regulation of protein depolymerization |
| positive regulation of axonogenesis |
| maintenance of location in cell |
| regulation of axon extension |
| positive regulation of plasma membrane bounded cell projection assembly |
| maintenance of protein location |
| response to retinoic acid |
| regulation of extent of cell growth |
| regulation of protein complex disassembly |
| growth cone |
| negative regulation of protein complex assembly |
| negative regulation of supramolecular fiber organization |
| cellular protein complex disassembly |
| negative regulation of cytoskeleton organization |
| positive regulation of cell morphogenesis involved in differentiation |
| positive regulation of cell growth |
| maintenance of location |
| regulation of actin filament polymerization |
| positive regulation of developmental growth |
| lamellipodium |
| regulation of cell size |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| regulation of axonogenesis |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| actin filament binding |
| cellular response to acid chemical |
| regulation of protein polymerization |
| protein-containing complex disassembly |
| actin filament organization |
| positive regulation of growth |
| regulation of actin filament organization |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| cadherin binding |
| regulation of developmental growth |
| regulation of actin cytoskeleton organization |
| response to acid chemical |
| regulation of supramolecular fiber organization |
| positive regulation of neuron differentiation |
| negative regulation of organelle organization |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| cellular component disassembly |
| regulation of cell growth |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| positive regulation of neurogenesis |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| regulation of anatomical structure size |
| cellular response to lipid |
| positive regulation of cellular component biogenesis |
| response to growth factor |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| actin filament-based process |
| regulation of neuron differentiation |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| regulation of neurogenesis |
| response to lipid |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| cytoskeleton organization |
| cell projection organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| positive regulation of developmental process |
| RNA binding |
| ATP binding |
| generation of neurons |
| response to oxygen-containing compound |
| cellular protein localization |
| cellular macromolecule localization |
| neurogenesis |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13053
- Expression level (log2 read counts): 5.33
Expression Distribution
TWF2 Expression in NALM6 Cells: 5.33
