TYROBP
Gene Information
- Official Symbol: TYROBP
- Official Name: transmembrane immune signaling adaptor TYROBP
- Aliases and Previous Symbols: N/A
- Entrez ID: 7305
- UniProt: O43914
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010].
- UniProt Summary: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of hippocampal neuron apoptotic process |
| negative regulation of interleukin-10 biosynthetic process |
| positive regulation of microglial cell mediated cytotoxicity |
| regulation of microglial cell mediated cytotoxicity |
| positive regulation of receptor localization to synapse |
| microglial cell activation involved in immune response |
| positive regulation of osteoclast development |
| regulation of hippocampal neuron apoptotic process |
| regulation of macrophage fusion |
| negative regulation of transforming growth factor beta1 production |
| positive regulation of macrophage fusion |
| regulation of interleukin-10 biosynthetic process |
| regulation of interleukin-1 biosynthetic process |
| positive regulation of interleukin-1 beta biosynthetic process |
| regulation of interleukin-1 beta biosynthetic process |
| positive regulation of interleukin-1 biosynthetic process |
| positive regulation of bone development |
| negative regulation of transforming growth factor beta production |
| positive regulation of protein localization to synapse |
| regulation of osteoclast development |
| regulation of transforming growth factor beta1 production |
| negative regulation of long-term synaptic potentiation |
| macrophage activation involved in immune response |
| positive regulation of interleukin-6 biosynthetic process |
| negative regulation of B cell proliferation |
| positive regulation of protein localization to cell surface |
| regulation of receptor localization to synapse |
| negative regulation of interleukin-10 production |
| positive regulation of superoxide anion generation |
| positive regulation of natural killer cell activation |
| positive regulation of tumor necrosis factor biosynthetic process |
| regulation of superoxide anion generation |
| regulation of interleukin-6 biosynthetic process |
| regulation of bone development |
| positive regulation of osteoclast differentiation |
| regulation of protein localization to synapse |
| positive regulation of syncytium formation by plasma membrane fusion |
| regulation of syncytium formation by plasma membrane fusion |
| negative regulation of B cell activation |
| regulation of tumor necrosis factor biosynthetic process |
| microglial cell activation |
| leukocyte activation involved in inflammatory response |
| negative regulation of cytokine biosynthetic process |
| regulation of natural killer cell activation |
| regulation of superoxide metabolic process |
| regulation of transforming growth factor beta production |
| regulation of protein localization to cell surface |
| glial cell activation |
| apoptotic cell clearance |
| neuroinflammatory response |
| regulation of long-term synaptic potentiation |
| osteoclast differentiation |
| response to axon injury |
| macrophage activation |
| positive regulation of interleukin-1 beta production |
| regulation of interleukin-10 production |
| cellular defense response |
| positive regulation of neuron apoptotic process |
| positive regulation of myeloid leukocyte differentiation |
| positive regulation of leukocyte mediated cytotoxicity |
| positive regulation of interleukin-1 production |
| regulation of B cell proliferation |
| regulation of osteoclast differentiation |
| positive regulation of cytokine biosynthetic process |
| positive regulation of cell killing |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| regulation of leukocyte mediated cytotoxicity |
| negative regulation of leukocyte proliferation |
| cell |
| regulation of interleukin-1 beta production |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of neuron death |
| positive regulation of myeloid cell differentiation |
| integrin-mediated signaling pathway |
| regulation of interleukin-1 production |
| positive regulation of interleukin-6 production |
| positive regulation of reactive oxygen species metabolic process |
| secretory granule membrane |
| regulation of cell killing |
| regulation of cytokine biosynthetic process |
| myeloid leukocyte differentiation |
| regulation of myeloid leukocyte differentiation |
| regulation of interleukin-6 production |
| negative regulation of lymphocyte activation |
| positive regulation of leukocyte differentiation |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of leukocyte activation |
| protein stabilization |
| regulation of reactive oxygen species metabolic process |
| positive regulation of hemopoiesis |
| regulation of synaptic plasticity |
| negative regulation of cell activation |
| regulation of neuron apoptotic process |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| myeloid cell differentiation |
| regulation of leukocyte proliferation |
| regulation of myeloid cell differentiation |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| apoptotic signaling pathway |
| regulation of protein stability |
| regulation of neuron death |
| positive regulation of cellular protein localization |
| phagocytosis |
| leukocyte differentiation |
| signaling receptor binding |
| positive regulation of lymphocyte activation |
| forebrain development |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| negative regulation of immune system process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| actin cytoskeleton organization |
| inflammatory response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of cellular protein localization |
| positive regulation of cell development |
| hemopoiesis |
| actin filament-based process |
| response to wounding |
| myeloid leukocyte activation |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| immune system development |
| positive regulation of programmed cell death |
| negative regulation of cell population proliferation |
| regulation of cytokine production |
| positive regulation of cell death |
| regulated exocytosis |
| brain development |
| innate immune response |
| leukocyte mediated immunity |
| head development |
| exocytosis |
| regulation of cellular localization |
| apoptotic process |
| leukocyte activation |
| regulation of cell development |
| defense response to other organism |
| positive regulation of cell differentiation |
| central nervous system development |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| programmed cell death |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| cell activation |
| immune effector process |
| cell death |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| secretion |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| integral component of plasma membrane |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8048
- Expression level (log2 read counts): -7.68
Expression Distribution
TYROBP Expression in NALM6 Cells: -7.68
