UCKL1
Gene Information
- Official Symbol: UCKL1
- Official Name: uridine-cytidine kinase 1 like 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 54963
- UniProt: Q9NWZ5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May contribute to UTP accumulation needed for blast transformation and proliferation. {ECO:0000269|PubMed:12199906}.
Pfam Domains GO Terms
Pfam Domains
| CPT |
| PRK |
GO Terms
| CTP salvage |
| uridine kinase activity |
| pyrimidine nucleotide salvage |
| pyrimidine ribonucleotide salvage |
| UMP salvage |
| pyrimidine ribonucleoside monophosphate metabolic process |
| UMP metabolic process |
| UMP biosynthetic process |
| pyrimidine ribonucleoside monophosphate biosynthetic process |
| pyrimidine-containing compound salvage |
| pyrimidine nucleoside salvage |
| nucleotide salvage |
| CTP metabolic process |
| CTP biosynthetic process |
| pyrimidine ribonucleoside triphosphate biosynthetic process |
| pyrimidine nucleoside biosynthetic process |
| nucleoside salvage |
| pyrimidine nucleoside monophosphate biosynthetic process |
| pyrimidine ribonucleoside triphosphate metabolic process |
| pyrimidine nucleoside monophosphate metabolic process |
| pyrimidine nucleoside triphosphate biosynthetic process |
| pyrimidine ribonucleotide biosynthetic process |
| pyrimidine nucleoside triphosphate metabolic process |
| pyrimidine ribonucleotide metabolic process |
| ribonucleoside monophosphate biosynthetic process |
| cellular metabolic compound salvage |
| pyrimidine nucleoside metabolic process |
| nucleoside biosynthetic process |
| glycosyl compound biosynthetic process |
| nucleoside monophosphate biosynthetic process |
| pyrimidine nucleotide biosynthetic process |
| ribonucleoside triphosphate biosynthetic process |
| ribonucleoside monophosphate metabolic process |
| pyrimidine-containing compound biosynthetic process |
| pyrimidine nucleotide metabolic process |
| nucleoside triphosphate biosynthetic process |
| ribonucleoside triphosphate metabolic process |
| nucleoside monophosphate metabolic process |
| kinase activity |
| nucleoside triphosphate metabolic process |
| pyrimidine-containing compound metabolic process |
| nucleobase-containing small molecule biosynthetic process |
| nucleoside metabolic process |
| glycosyl compound metabolic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| ribonucleotide metabolic process |
| ribose phosphate metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| viral process |
| symbiotic process |
| interspecies interaction between organisms |
| organophosphate metabolic process |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| ATP binding |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| AICAR 240μM R03 exp116 | -1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8306
- Expression level (log2 read counts): 5.05
Expression Distribution
UCKL1 Expression in NALM6 Cells: 5.05
