VAMP7
Gene Information
- Official Symbol: VAMP7
- Official Name: vesicle associated membrane protein 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 6845
- UniProt: P51809
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010].
- UniProt Summary: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. {ECO:0000269|PubMed:10888671, ECO:0000269|PubMed:16677249, ECO:0000269|PubMed:18042464}.
Pfam Domains GO Terms
Pfam Domains
| Synaptobrevin |
GO Terms
| regulation of protein targeting to vacuolar membrane |
| positive regulation of histamine secretion by mast cell |
| eosinophil mediated immunity |
| eosinophil activation involved in immune response |
| eosinophil activation |
| eosinophil degranulation |
| regulation of vacuolar transport |
| triglyceride transport |
| acylglycerol transport |
| natural killer cell degranulation |
| regulation of histamine secretion by mast cell |
| vesicle fusion with Golgi apparatus |
| SNARE complex assembly |
| platelet alpha granule |
| positive regulation of mast cell degranulation |
| positive regulation of mast cell activation involved in immune response |
| pseudopodium |
| positive regulation of mast cell activation |
| positive regulation of leukocyte degranulation |
| natural killer cell activation involved in immune response |
| natural killer cell mediated cytotoxicity |
| natural killer cell mediated immunity |
| positive regulation of myeloid leukocyte mediated immunity |
| SNAP receptor activity |
| autophagosome maturation |
| integral component of synaptic vesicle membrane |
| regulation of mast cell degranulation |
| hippocampal mossy fiber to CA3 synapse |
| Golgi to plasma membrane protein transport |
| regulation of mast cell activation involved in immune response |
| regulation of protein targeting to membrane |
| positive regulation of neurotransmitter transport |
| positive regulation of dendrite morphogenesis |
| leukocyte mediated cytotoxicity |
| calcium-ion regulated exocytosis |
| vesicle transport along microtubule |
| regulation of mast cell activation |
| SNARE complex |
| vesicle cytoskeletal trafficking |
| regulation of leukocyte degranulation |
| establishment of protein localization to plasma membrane |
| endosome to lysosome transport |
| clathrin-coated vesicle membrane |
| positive regulation of regulated secretory pathway |
| syntaxin binding |
| natural killer cell activation |
| regulation of myeloid leukocyte mediated immunity |
| azurophil granule membrane |
| phagocytic vesicle |
| Golgi to plasma membrane transport |
| SNARE binding |
| vesicle fusion |
| apical part of cell |
| phagocytic vesicle membrane |
| positive regulation of dendrite development |
| organelle membrane fusion |
| organelle transport along microtubule |
| regulation of protein targeting |
| secretory granule |
| cell killing |
| positive regulation of exocytosis |
| regulation of dendrite morphogenesis |
| vesicle-mediated transport to the plasma membrane |
| organelle fusion |
| secretory granule membrane |
| post-Golgi vesicle-mediated transport |
| lysosomal transport |
| lymphocyte activation involved in immune response |
| late endosome membrane |
| positive regulation of hormone secretion |
| phagocytosis, engulfment |
| membrane fusion |
| positive regulation of leukocyte mediated immunity |
| plasma membrane invagination |
| positive regulation of inflammatory response |
| vacuolar transport |
| regulation of neurotransmitter transport |
| membrane invagination |
| regulation of dendrite development |
| positive regulation of cell morphogenesis involved in differentiation |
| transport along microtubule |
| macroautophagy |
| regulation of regulated secretory pathway |
| trans-Golgi network |
| establishment of vesicle localization |
| cytoskeleton-dependent intracellular transport |
| lamellipodium |
| microtubule-based transport |
| protein localization to plasma membrane |
| vesicle localization |
| regulation of protein localization to membrane |
| regulation of leukocyte mediated immunity |
| positive regulation of intracellular transport |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| positive regulation of immune effector process |
| regulation of exocytosis |
| protein localization to cell periphery |
| regulation of intracellular protein transport |
| protein-containing complex disassembly |
| autophagy |
| process utilizing autophagic mechanism |
| establishment of protein localization to membrane |
| lymphocyte mediated immunity |
| regulation of hormone secretion |
| microtubule-based movement |
| positive regulation of ion transport |
| positive regulation of neuron projection development |
| lipid transport |
| lysosomal membrane |
| vesicle organization |
| regulation of cell morphogenesis involved in differentiation |
| lipid localization |
| neuron projection |
| phagocytosis |
| regulation of inflammatory response |
| regulation of intracellular transport |
| establishment of organelle localization |
| positive regulation of neuron differentiation |
| Golgi vesicle transport |
| positive regulation of cell projection organization |
| lymphocyte activation |
| cellular component disassembly |
| positive regulation of leukocyte activation |
| positive regulation of secretion by cell |
| positive regulation of cell activation |
| positive regulation of secretion |
| regulation of immune effector process |
| positive regulation of neurogenesis |
| positive regulation of defense response |
| protein localization to membrane |
| neutrophil degranulation |
| regulation of cell morphogenesis |
| neutrophil activation involved in immune response |
| regulation of neuron projection development |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of hormone levels |
| positive regulation of nervous system development |
| regulation of cellular protein localization |
| positive regulation of cell development |
| cell junction |
| regulation of vesicle-mediated transport |
| endocytosis |
| organelle localization |
| myeloid leukocyte activation |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| regulation of neuron differentiation |
| microtubule-based process |
| import into cell |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulated exocytosis |
| regulation of protein transport |
| regulation of cell projection organization |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| leukocyte mediated immunity |
| innate immune response |
| exocytosis |
| regulation of secretion |
| regulation of neurogenesis |
| cellular protein-containing complex assembly |
| membrane organization |
| positive regulation of immune response |
| regulation of cellular localization |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| endoplasmic reticulum membrane |
| defense response to other organism |
| positive regulation of cell differentiation |
| positive regulation of transport |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| regulation of anatomical structure morphogenesis |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| secretion |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of cellular component organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16489
- Expression level (log2 read counts): 5.15
Expression Distribution
VAMP7 Expression in NALM6 Cells: 5.15
