WDR25

Entrez Summary: This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 39/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	2/26
breast	2/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	1/75
lymphocyte	0/16
ovary	2/26
pancreas	0/24
peripheral nervous system	5/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	1/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	1/5

Expression Distribution