WDR36
Gene Information
- Official Symbol: WDR36
- Official Name: WD repeat domain 36
- Aliases and Previous Symbols: N/A
- Entrez ID: 134430
- UniProt: Q8NI36
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008].
- UniProt Summary: Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2. {ECO:0000269|PubMed:21051332}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1264
- Expression level (log2 read counts): 7.32
WDR36 Expression in NALM6 Cells: 7.32
