Entrez Summary: This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
C8
VWD
MAM
TIL
TILa
GO Terms
binding of sperm to zona pellucida
sperm-egg recognition
cell-cell recognition
single fertilization
fertilization
cell recognition
cell-cell adhesion
sexual reproduction
cell adhesion
biological adhesion
multi-organism reproductive process
reproductive process
reproduction
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)