ZNF639
Gene Information
- Official Symbol: ZNF639
- Official Name: zinc finger protein 639
- Aliases and Previous Symbols: N/A
- Entrez ID: 51193
- UniProt: Q9UID6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds DNA and may function as a transcriptional repressor. {ECO:0000269|PubMed:16182284}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| negative regulation by host of viral transcription |
| positive regulation by host of viral transcription |
| negative regulation of viral transcription |
| positive regulation of viral transcription |
| protein self-association |
| regulation of viral transcription |
| modification by host of symbiont morphology or physiology |
| interaction with symbiont |
| viral entry into host cell |
| negative regulation of viral process |
| entry into host cell |
| entry into host |
| positive regulation of viral process |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| modification of morphology or physiology of other organism |
| interaction with host |
| positive regulation of cell growth |
| viral life cycle |
| regulation of viral process |
| negative regulation of multi-organism process |
| transcription regulatory region DNA binding |
| regulation of symbiosis, encompassing mutualism through parasitism |
| positive regulation of growth |
| regulation of cell growth |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| positive regulation of multi-organism process |
| regulation of growth |
| DNA-binding transcription factor activity |
| viral process |
| regulation of multi-organism process |
| symbiotic process |
| interspecies interaction between organisms |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pyridostatin 4μM R05 exp240 | -1.88 |
| 39°C R06 exp303 | -1.77 |
| Mitomycin-C 0.06μM R08 exp503 | -1.73 |
| CoCl2 18μM R07 exp346 | 1.91 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16367
- Expression level (log2 read counts): 6.34
Expression Distribution
ZNF639 Expression in NALM6 Cells: 6.34
