ZNF674

Entrez Summary: This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mental retardation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010].
UniProt Summary: May be involved in transcriptional regulation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
FK-506 5μM R07 exp358	-1.76

Global Fraction of Cell Lines Where Essential: 45/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	1/26
bone	3/26
breast	4/30
central nervous system	5/49
cervix	0/4
colorectal	3/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	2/18
liver	2/19
lung	2/72
lymphocyte	1/16
ovary	1/25
pancreas	0/22
peripheral nervous system	2/15
plasma cell	0/12
prostate	1/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	3/28
uterus	1/5

Expression Distribution