AADAC

Entrez Summary: N/A
UniProt Summary: Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000269|PubMed:17936933, ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931, ECO:0000269|PubMed:23542347}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

COesterase
Abhydrolase 3

serine hydrolase activity
positive regulation of triglyceride catabolic process
deacetylase activity
regulation of triglyceride catabolic process
positive regulation of triglyceride metabolic process
triglyceride lipase activity
lipase activity
positive regulation of lipid catabolic process
regulation of triglyceride metabolic process
catalytic activity
regulation of lipid catabolic process
xenobiotic metabolic process
positive regulation of lipid metabolic process
cellular response to xenobiotic stimulus
response to xenobiotic stimulus
positive regulation of cellular catabolic process
regulation of lipid metabolic process
positive regulation of catabolic process
regulation of cellular catabolic process
endoplasmic reticulum membrane
regulation of catabolic process