AADAT

Entrez Summary: N/A
UniProt Summary: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). {ECO:0000269|PubMed:18620547}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Aminotran 1 2
Aminotran MocR

2-aminoadipate transaminase activity
L-lysine catabolic process to acetyl-CoA via saccharopine
L-lysine metabolic process
L-lysine catabolic process to acetyl-CoA
kynurenine-oxoglutarate transaminase activity
L-lysine catabolic process
transaminase activity
L-kynurenine metabolic process
tryptophan catabolic process
indole-containing compound catabolic process
indolalkylamine catabolic process
kynurenine metabolic process
lysine catabolic process
tryptophan metabolic process
lysine metabolic process
2-oxoglutarate metabolic process
indolalkylamine metabolic process
cellular biogenic amine catabolic process
amine catabolic process
aspartate family amino acid catabolic process
indole-containing compound metabolic process
benzene-containing compound metabolic process
aromatic amino acid family catabolic process
acetyl-CoA metabolic process
glutamate metabolic process
aromatic amino acid family metabolic process
aspartate family amino acid metabolic process
pyridoxal phosphate binding
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
glutamine family amino acid metabolic process
cellular ketone metabolic process
dicarboxylic acid metabolic process
thioester metabolic process
acyl-CoA metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process